Introducing SAMatrix™ Technology
SAMatrix™ (Synthetic Antimicrobial Matrix) technology — or SAM, for short — was developed to address the complex, multifactorial needs of serious wounds.
SAM is the platform technology behind Imbed Biosciences’ portfolio of FDA-cleared, USA-made, advanced wound matrices designed for diverse clinical settings.


SAMatrix™ Technology is now available in a PainGuard® version containing lidocaine to help manage infection risk and pain in one solution. Click here to learn more!
SAMatrix™ is the First and Only Fully Synthetic, Antimicrobial, Biocompatible Matrix
SAMatrix™ Technology addresses needs of complex wounds with its ability to integrate various wound care agents into a single matrix — delivering a one-product solution that provides multiple advantages across the wound healing process.
SAMatrix™ can be used at the onset of wound treatment following debridement or in surgery, including in conjunction with other wound management technologies and solutions.

Unique Synthetic and Conformable Matrix
- The ultra-thin, fully synthetic and porous matrix is composed of a proprietary blend of resorbable polymers, is non-pyrogenic, and does not require removal following application. The matrix is resorbed in as little as one week.8
- Upon contact with wound fluid, SAMatrix™ conforms to the micro-textures of the wound bed, in close contact with microbes on the tissue surface and in a way that helps to prevent voids for bacteria to proliferate and exudate to pool.
- SAMatrix™ is also permeable to oxygen and moisture vapor.11
- SAMatrix™ does not contain any human or animal-derived tissues or cells. Risks or opposition generally associated with allograft or xenograft products do not exist.


Ideal Moist Wound-Healing Environment
- Hydrophilic polyvinyl alcohol (PVA) in SAMatrix™ absorbs wound fluid and helps maintain ideal moisture right where it is needed to create a cytophilic, moist wound-healing environment.11


The “SAMatrix™ Scaffolding Effect”
- No thicker than a human hair, the matrix’s PEM (polyelectrolyte multilayers) surface has an ideal mechanical strength to enable cells to attach, adhere, migrate, and proliferate — this is the “SAMatrix™ Scaffolding Effect“.
- This cytophilic (“cell friendly”) matrix is designed to mimic human ECM4,8,10 and in studies12 has demonstrated its support of healthy and uniform cell growth:


Sustained Antimicrobial Activity
- The surface coating architecture of SAMatrix™ is optimized to contain a low and safe level of evenly distributed metallic and ionic silver to deliver rapid, effective, and sustained antimicrobial action for up to 72 hours.
- SAMatrix™ is microbicidal on most types of clinically relevant pathogens, including MRSA, VRE and Pseudomonas, even with only containing a low level of silver.

SAMatrix™’s architecture, coupled with its ability to conform to wound crevices, together create SAMatrix™’s antimicrobial advantage.
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