Healthcare Professional Microlyte® Matrix FAQs

What do I cover Microlyte® Matrix with after I apply it to the wound?
Microlyte® Matrix should be covered with a non-adherent dressing and any other dressings needed to maintain a moist wound environment. Change the cover dressing as needed to maintain a moist wound environment or when Microlyte®Matrix is reapplied.

Can I cut Microlyte® Matrix?
Absolutely. Microlyte® Matrix should be cut to size slightly larger than the wound. Multiple pieces may be used to cover the wound bed and the wound margin.

What if the wound is dry?
We recommend that a dry wound be moistened with sterile saline after routine debridement and prior to application of Microlyte® Matrix

How often do I need to reapply Microlyte® Matrix?
Reapply Microlyte® Matrix depending on the wound and the healing progression, or when clinically indicated. To reapply, carefully remove the cover dressing(s). Gently irrigate wound with sterile saline to remove necrotic tissue. It is not necessary to remove any residual Microlyte® Matrix observed during cover dressing changes.

How do I remove Microlyte® Matrix from the wound?
Once Microlyte® Matrix is applied to the wound bed, the matrix essentially becomes one with the wound.  As it is fully resorbable, there is no need to actively remove the product from the wound bed prior to reapplication. If removal is necessary, Microlyte® Matrix can be removed by gentle irrigation with sterile saline.

Is the silver harmful to the periwound skin?
No. Because of the conformal nature of Microlyte® Matrix, it contains a very low amount of silver that is still effective on most types of common wound microbes.

Can Microlyte® Matrix be used with patients who will undergo MRI?
Yes, Microlyte® Matrix has been demonstrated compatible with magnetic resonance imaging.

What is the mechanism of action of Microlyte® Matrix?
Microlyte® Matrix facilitates healing in acute and chronic wounds through the matrix function of the PEM nanofilm. The PEM component of Microlyte® Matrix contains both anionic and cationic charged polymeric components which serve to shield approaching granulation cells from the generally disorganized surface chemistry common to wound beds. This masking provides a functional molecular matrix or template to facilitate the granulation process in the healing wound. The ultrathin formfactor of Microlyte® Matrix allows it to rapidly absorb wound fluid and transform into a bioresorbable material that intimately contours to the underlying wound bed. This places the matrix directly on the wound bed where it is most beneficial to the healing process. The hydrophilic resorbable polyvinyl alcohol (PVA) in Microlyte® Matrix maintains a physiologically moist microenvironment in the wound, which further facilitates wound healing.

Microlyte® Matrix is so thin compared to other matrices. How is it so effective?
The ultrathin form factor of Microlyte® Matrix is actually the key. It allows Microlyte® Matrix to conform tightly to the wound bed and brings the matrix functionality to the “nooks and crannies” of the wound. Comparatively bulky macro-scale matrices sit well above the wound bed and force the granulation cells to come to them.

Is Microlyte® Matrix active against resistant microorganisms such as Methicillin Resistant Staphylococcus aureus (MRSA) or Vancomycin Resistant Enterococcus (VRE)?

Microlyte® Matrix has been demonstrated in vitro to be effective against a number of micro organisms including:

  • Methicillin Resistant Staphylococcus aureus (MRSA)
  • Vancomycin Resistant Enterococcus (VRE)
  • Pseudomonas aeruginosa
  • Klebsiella pneumoniae
  • Staphylococcus aureus
  • Escherichia coli
  • Candida tropicalis
  • Candida albicans

Is Microlyte® Matrix compatible with various cleansing agents?
Many agents or solutions have been traditionally used to cleanse wounds. We have tested Microlyte® Matrix specifically with hypochlorous acid cleansers and found them to be compatible.

Can you overlap Microlyte® Matrix?
Yes, Microlyte® Matrix may be overlapped without any concern.